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Critical Illness: Individuals who have respiratory failure, septic shock, and/or multiple organ dysfunction.Severe Illness: Individuals who have SpO 2 30 breaths/min, or lung infiltrates >50%.Moderate Illness: Individuals who show evidence of lower respiratory disease during clinical assessment or imaging and who have an oxygen saturation (SpO 2) ≥94% on room air at sea level.Mild Illness: Individuals who have any of the various signs and symptoms of COVID-19 (e.g., fever, cough, sore throat, malaise, headache, muscle pain, nausea, vomiting, diarrhea, loss of taste and smell) but who do not have shortness of breath, dyspnea, or abnormal chest imaging.Asymptomatic or Presymptomatic Infection: Individuals who test positive for SARS-CoV-2 using a virologic test (i.e., a nucleic acid amplification test or an antigen test) but who have no symptoms that are consistent with COVID-19.In general, adults with SARS-CoV-2 infection can be grouped into the following severity of illness categories however, the criteria for each category may overlap or vary across clinical guidelines and clinical trials, and a patient’s clinical status may change over time. Patients with SARS-CoV-2 infection can experience a range of clinical manifestations, from no symptoms to critical illness.